Publications 2021
Tarkhnishvili A, Koentges C, Pfeil K, Gollmer J, Byrne NJ, Vosko I, Lueg J, Vogelbacher L, Birkle S, Tang S, Bon-Nawul Mwinyella T, Hoffmann MM, Odening KE, Anto Michel N, Wolf D, Stachon P, Hilgendorf I, Wallner M, Ljubojevic-Holzer S, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Zirlik A, Bugger H. Effects of short term adiponectin receptor agonism on cardiac function and
energetics in diabetic db/db mice. J Lipid Atheroscler. 2021; in press
Gollmer J, Zirlik A, Bugger H. Der herzkranke Diabetespatient. Kardio up2date. 2021; in press
Bugger H, Zirlik A. Anti-inflammatory strategies in atherosclerosis. Hämostaseologie. 2021; in press
Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021;169:317-342
Smolka C, Schlösser D, Koentges C, Tarkhnishvili A, Gorka O, Pfeifer D, Bemtgen X, Asmussen A, Gross O, Diehl P, Moser M, Bode C, Bugger H, Grundmann S, Pankratz F. Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36. FASEB J. 2021;35(11):e21956
Gissler MC, Anto-Michel N, Pennig J, Scherrer P, Li X, Marchini T, Pfeiffer K, Härdtner C, Abogunloko T, Mwinyella T, Sol Mitre L, Spiga L, Koentges C, Smolka C, von Elverfeldt D, Hoppe N, Stachon P, Dufner B, Heidt T, Piepenburg S, Hilgendorf I, Bjune JI, Dankel SN, Mellgren G, Seifert G, Eisenhardt SU, Bugger H, von Zur Muhlen C, Bode C, Zirlik A, Wolf D, Willecke F. Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. Arterioscler Thromb Vasc Biol. 2021;41(10):2563-2574.
Sedej S, Bugger H. Editorial of Special Issue “Sirtuins in health and disease”. Int J Mol Sci. 2021; 22(10):5054
Bauer A, Schreinlechner M, Sappler N, Dolejsi T, Tilg H, Aulinger BA, Weiss G, Bellmann-Weiler R, Adolf C, Wolf D, Pirklbauer M, Graziadei I, Gänzer H, von Bary C, May AE, Wöll E, von Scheidt W, Rassaf T, Duerschmied D, Brenner C, Kääb S, Metzler B, Joannidis M, Kain HU, Kaiser N, Schwinger R, Witzenbichler B, Alber H, Straube F, Hartmann N, Achenbach S, von Bergwelt-Baildon M, von Stülpnagel L, Schoenherr S, Forer L, Embacher-Aichhorn S, Mansmann U, Rizas KD, Massberg S. Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial. Lancet Respir Med. 2021;9(8):863-872.
Gollmer J, Bugger H. Interatrialer Shunt zur Therapie der Herzinsuffizienz. J Kardiol. 2021;28(3-4):98-102
Tomin T, Schittmayer M, Sedej S, Bugger H, Gollmer J, Honeder S, Darnhofer B, Liesinger L, Zuckermann A, Rainer PP, Birner-Gruenberger R. Mass spectrometry-based redox and protein profiling of failing human hearts. Int J Mol Sci. 2021;22(4):1787
Publications 2020
Bugger H, Gollmer J, Pregartner G, Wünsch G, Berghold A, Zirlik A, von Lewinski D. Complications and mortality of cardiovascular emergency admissions during COVID-19 associated restrictive measures. PlOS One. 2020;15(9):e0239801
Koyani CN, Plastira I, Sourij H, Hallström S, Schmidt A, Rainer PP, Bugger H, Frank S, Malle E, von Lewinski D. Empagliflozin protects heart from inflammation and energy depletion via AMPK activation. Pharmacol Res. 2020;158:104870.
Bugger H, Pfeil K. Mitochondrial ROS in myocardial ischemia reperfusion and remodeling. Biochim Biophys Acta. 2020;Mar 12 Epub ahead of print
Gollmer J, Zirlik A, Bugger H. Mitochondrial Mechanisms in Diabetic Cardiomyopathy. Diabetes Metab J. 2020;44(1):33-53
Wallner M, Eaton DM, Berretta RM, Liesinger L, Schittmayer M, Gindlhuber J, Wu J, Jeong MY, Lin YH, Borghetti G, Baker ST, Zhao H, Pfleger J, Blass S, Rainer PP, von Lewinski D, Bugger H, Mohsin S, Graier WF, Zirlik A, McKinsey TA, Birner-Gruenberger R, Wolfson MR, Houser SR. HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction. Sci Transl Med 2020;12:525
Publications 2019
Gollmer J, Zirlik A, Bugger H. Established and emerging mechanisms of diabetic cardiomyopathy. J Lipid Atheroscl. 2019;8(1):26-47
Gollmer J, Bugger H. Mechanisms underlying heart failure in type 2 diabetes mellitus. Heart Metab2019;80:37-39
Pepin ME, Koentges C, Pfeil K, Gollmer J, Kersting S, Wiese S, Hoffmann MM, Odening KE, von zur Mühlen C, Diehl P, Stachon P, Wolf D, Wende AR, Bode C, Zirlik A, Bugger H. Dysregulation of the mitochondrial proteome occurs in mice lacking adiponectin receptor 1. Front Endocrinol. 2019;10:872
Ramadani-Muja J, Gottschalk B, Pfeil K, Burgstaller S, Rauter T, Bischof H, Waldeck-Weiermair M, Bugger H, Graier WF, Malli R. Visualization of sirtuin 4 distribution between mitochondria and the nucleus, based on bimolecular fluorescence self-complementation. Cells 2019;8(12):E1583
Dangas GD, Tijssen JGP, Wöhrle J, Søndergaard L, Gilard M, Möllmann H, Makkar RR, Herrmann HC, Giustino G, Baldus S, De Backer O, Guimarães AHC, Gullestad L, Kini A, von Lewinski D, Mack M, Moreno R, Schäfer U, Seeger J, Tchétché D, Thomitzek K, Valgimigli M, Vranckx P, Welsh RC, Wildgoose P, Volkl AA, Zazula A, van Amsterdam RGM, Mehran R, Windecker S; GALILEO Investigators. A controlled trial of rivaroxaban after transvatheter aortic-valve replacement. N Engl J Med. 2019;382(2):120-129
Koentges C, Cimolai MC, Pfeil K, Wolf D, Marchini T, Tarkhnishvili A, Hoffmann MM, Odening KE, Diehl P, von zur Mühlen C, Alvarez S, Bode C, Zirlik A, Bugger H. Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. J Mol Cell Cardiol. 2019; 133:138-147
Ahlgrimm B, Pottgiesser T, Stachon P, Zehender M, Bugger H, Helbing T, Siepe M, Grundmann S, Bode C, Diehl P. The cardia ultraseal left atrial appendage occluder: A case series with significant device-related complications. J Am Coll Cardiol Cardiovasc Interv. 2019; 12(19):1987-1989
Odening KE, Bodi I, Franke G, Rieke R, Ryan de Medeiros A, Perez-Feliz S, Fürniss H, Mettke L, Michaelides K, Lang CN, Steinfurt J, Pantulu ND, Ziupa D, Menza M, Zehender M, Bugger H, Peyronnet R, Behrends JC, Doleschall Z, Zur Hausen A, Bode C, Jolivet G, Brunner M. Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility. Eur Heart J.2019;40(10):842-853
Bodi I, Sorge J, Castiglione A, Glatz SM, Wuelfers EM, Franke G, Perez-Feliz S, Koren G, Zehender M, Bugger H, Seemann G, Brunner M, Bode C, Odening KE. Postpartum hormones oxytocin and prolactin cause proarrhythmic prolongation of cardiac repolarization in long QT syndrome type 2. Europace 2019;21(7):1126-1138
Wiviott SD, Raz I, Bonoca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Frederiksson M, Johansson PA, Langkilde AM, Sabatine MS; DECLARE-TIMI 58 Investigators. N Engl J Med. 2019;380(4):347-357
Publications 2018
Ziupa D, Menza M, Koppermann S, Moss R, Beck J, Franke G, Perez Feliz S, Brunner M, Mayer S, Bugger H, Koren G, Zehender M, Jung BA, Seemann G, Foell D, Bode C, Odening KE. Electro-mechanical (dys-)function in long QT syndrome type 1. Int J Cardiol. 2019; 274:144-151
Tsushima K*, Bugger H*, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Black CL, Pereira RO, Lira VA, Spitzer K, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018; 122(1):58-73 *equally contributed
Merz J, Albrecht P, von Garlen S, Ahmed I, Dimanski D, Wolf D, Hilgendorf I, Härdtner C, Grotius K, Willecke F, Heidt T, Bugger H, Hoppe N, Kintscher U, von Zur Mühlen C, Idzko M, Bode C, Zirlik A, Stachon P. Purinergic receptor Y2 (P2Y2)-dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome. Basic Res Cardiol. 2018;113(6):45
Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Dei Cas A, González A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP, Rosano G, Staels B, van Laake LW, Wanner C, Farmakis D, Filippatos G, Ruschitzka F, Seferovic P, de Boer RA, Heymans S. Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology. Eur Heart J. 2018; 39(48): 4243-4254
Mauler M, Herr N, Schoenichen C, Witsch T, Marchini T, Härdtner C, Koentges C, Kienle K, Ollivier V, Schell M, Dorner L, Wippel C, Stallmann D, Normann C, Bugger H, Walther P, Wolf D, Ahrens I, Lämmermann T, Ho-Tin-Noe B, Ley K, Bode C, Hilgendorf I, Duerschmied D. Platelet serotonin aggravates myocardial ischemia/reperfusion injury via neutrophil degranulation. Circulation 2018; 139(7):918-931
Diehl P, Gaul DS, Sogl J, Flierl U, Henstridge D, Pahla J, Bugger H, Emmert MY, Ruschitzka F, Bode C, Lüscher TF, Moser M, Matter CM, Peter K, Winnik S. The effect of oxygen in Sirt3-mediated myocardial protection: a proof-of-concept study in cultured cardiomyoblasts. J Thromb Thrombolysis. 2018; 46(1):102-112
Publications 2017
Koentges C, Pepin ME, Müsse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H*. Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans. Basic Res Cardiol. 2017;113(1):8 * equally contributed
Dressler FF, Bodi I, Menza M, Moss R, Bugger H, Bode C, Behrends JC, Seemann G, Odening KE. Interregional electro-mechanical heterogeneity in the rabbit myocardium. Prog Biophys Mol Biol. 2017;130:344-355
Brado J, Dechant MJ, Menza M, Komancsek A, Lang CN, Bugger H, Foell D, Jung BA, Stiller B, Bode C, Odening KE. Phase-contrast magnet resonance imaging reveals regional, transmural, and base-to-apex dispersion of mechanical dysfunction in patients with long QT syndrome. Heart Rhythm. 2017;14(9):1388-1397
Publications 2016
Bodi I, Grünert SC, Becker N, Stoelzle-Feix S, Spiekerkoetter U, Zehender M, Bugger H, Bode C, Odening KE. Mechanisms of aquired long QT syndrome in patients wth propionic acidemia. Heart Rhythm. 2016;13(6):1335-45
Bugger H, Witt CN, Bode C. Mitochondrial sirtuins in the heart. Heart Fail Rev. 2016; 21(5):519-28
Koentges C, Bode C, Bugger H. SIRT3 in cardiac physiology and disease. Front Cardiovasc Med. 2016;3:38
Hölscher ME, Bode C, Bugger H. Diabetic cardiomyopathy: Does the type of diabetes matter? Int J Mol Sci2016; 17(12):E2136
Koentges C, Pfeil K, Meyer-Steenbuck M, Lother A, Hoffmann MM, Odening KE, Hein L, Bode C, Bugger H. Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. Can J Physiol Pharmacol. 2016;94(1):72-80
Publications 2015
Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, Abel ED, Bode C, Bugger H. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol.2015;110(4):495
Koentges C, Pfeil K, Schnick T, Wiese S, Dahlbock R, Cimolai MC, Meyer-Steenbuck M, Cenkerova K, Hoffmann MM, Jaeger C, Odening KE, Kammerer B, Hein L, Bode C, Bugger H. SIRT3 deficiency impairs mitochondrial and contractile function in the heart. Basic Res Cardiol. 2015;110(4):493
Braun M, Hettinger N, Koentges C, Pfeil K, Cimolai MC, Hoffmann MM, Osterloh M, Doenst T, Bode C, Bugger H. Myocardial mitochondrial and contractile function are preserved in mice lacking adiponectin. PLOS One. 2015;10(3):e0119416
Lang CN, Menza M, Jochem S, Franke G, Feliz SP, Brunner M, Koren G, Zehender M, Bugger H, Jung BA, Foell D, Bode C, Odening KE. Electro-mechanical dysfunction in long QT syndrome: Role for arrhythmogenic risk prediction and modulation by sex and sex hormones. Prog Biophys Mol Biol. 2015;120(1-3):255-69
Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L. Adrenergic repression of the epigenetic reader MeCP2 facilitates cardiac adaptation in chronic heart failure. Circ Res. 2015;117(7):622-633
Ilkun O, Wilde N, Tuinei J, Pires KMP, Zhu Y, Bugger H, Soto J, Wayment B, Olsen C, Litwin SE, Abel ED. Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome. J Mol Cell Cardiol. 2015;85:104-116
Wende AR, O`Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. Akt/PKB signaling induces mitochondrial dysfunction in pathological cardiac hypertrophy via transcriptional repression of nuclear-encoded mitochondrial genes. Mol Cell Biol. 2015;35(5):831-46
Bugger H. Diabetic cardiomyopathy, does it exist? Heart Metab. 2015;68:35-38
Cimolai MC, Alvarez S, Bode C, Bugger H. Mitochondrial mechanisms in septic cardiomyopathy. Int J Mol Sci. 2015;16(8):17763-78